Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation

PI3K plays a key role in cellular metabolism and cancer. Using a mass spectrometry-based metabolomics platform, we discovered that plasma concentrations of 26 metabolites, including amino acids, acylcarnitines, and phosphatidylcholines, were decreased in mice bearing PTEN-deficient tumors compared w...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	Ang, Joo Ern, Pandher, Rupinder, Ang, Joo Chew, Asad, Yasmin J, Henley, Alan T, Valenti, Melanie, Box, Gary, de, Haven Brandon Alexis, Baird, Richard, Friedman, Lori, Derynck, Mika, Vanhaesebroeck, Bart, Eccles, Suzanne A, Kaye, Stan B, Workman, Paul, de, Bono Johann S, Raynaud, Florence I
Weitere Verfasser:	Antwerp X-ray Analysis, Electrochemistry and Speciation (AXES)
Sprache:	Englisch
Veröffentlicht:	American Association for Cancer Research 2019
Online-Zugang:	https://demo7.dspace.org/handle/123456789/449
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